Midway by means of his vocation, Cees Dekker reinvented himself. Soon after years of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the switch of the millennium. A phrase he coined himself, for a make a difference of actuality.
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
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Non-equilibrium folding of individual DNA molecules recaptured nearly one thousand times in a very sound point out nanopore
This yielded a breakthrough. Inside of just a few months, we were being capable of measure transportation by an individual single-walled carbon nanotube. Depending on lower-temperature experiments by a superb PhD university student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technologies with the Energetic investigation lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes ended up legitimate quantum wires with pretty long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Microbiology has only been around for any century, considering that we began to analyze micro-organisms extra seriously. I thought nanobiology was an appropriate term, simply because all molecular biological pertinent interactions take place on the nanoscale: a protein is several nanometres in measurement, DNA is 2 nm thick.’
All parameters have been the exact same for every panel in this video, except for the Preliminary placement on the 6hb rod (demonstrated in blue) on the nanopore. Simulations that terminated early because of translocation from the rod throughout the pore are marked by a grey qualifications.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
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Bulk-area coupling identifies the mechanistic relationship amongst Min-protein styles in vivo As well as in vitro
Tests pseudotopological and nontopological products for SMC-pushed DNA loop extrusion versus roadblock-traversal experiments
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim in the pore is highlighted in pink, as well as a 3D rendering of the motion of the DNA rod is shown.